Thermo Fisher Scientific MARVELD2/Tricellulin Polyclonal Antibody
MARVELD2/Tricellulin 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 액상 형태로 4°C에서 보관. 상피세포의 삼세포 간 밀착연접 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 40–90 of MARVELD2 (UniProt ID: Q8N4S9-1, Human, antigen length: 558 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 40 µg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Tight junctions form an important barrier for paracellular transport in epithelial cells. Tricellulin is the first protein identified to specifically concentrate in tricellular tight junctions, where three adjacent cells meet. It possesses four membrane-spanning domains similar to claudins and is highly expressed in epithelial tissues such as small intestine, kidney, and lung.
Functional studies using siRNA show that suppression of tricellulin expression compromises epithelial barrier integrity and tight junction formation. Mutations in tricellulin that remove conserved regions in its cytosolic domain, which interacts with scaffolding protein ZO-1, highlight its critical role in tight junction structure and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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