Thermo Fisher Scientific ABCA7 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ABCA7 protein. Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C. For research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,500 | — |
| Immunoprecipitation (IP) | Assay-dependent | — |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 2096–2146 of human ABCA7 (UniProt ID: Q8IZY2-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of multiple membrane-spanning domains plus Walker motifs for ATP interaction.
ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. High expression levels of ABCA7 in peripheral leukocytes, thymus, spleen, and bone marrow suggest a role in immune system lipid homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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