Thermo Fisher Scientific MIA Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total MIA protein.

Target Information

Tumorigenesis is a process mediated by a network of membrane, cytosolic, and nuclear-associated factors that regulate proliferation and cell-matrix interaction through signaling cascades.
Melanoma inhibitory activity (MIA, also known as cartilage-derived retinoic acid-sensitive protein, CD-RAP) is a Src homology 3 (SH3)-like domain-containing protein secreted from chondrocytes and malignant melanoma cells.
MIA is translated as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after cleavage of a secretion signal. It is expressed during chondrogenesis and in mature chondrocytes, suggesting a role in maintaining normal cartilage phenotype.
MIA mRNA is also present in carcinomas of the colon, ovary, kidney, and head/neck, and may serve as a marker to monitor melanomic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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