Thermo Fisher Scientific Interleukin-31/IL-33 Monoclonal Antibody (IL31/7333)
인간 IL-31 단백질을 인식하는 Mouse IgG 단일클론 항체로, IHC(P) 실험에 1–2 µg/mL 농도로 사용 가능. Protein A/G 정제 및 PBS + 0.05% BSA 완충액에 보관되며, 4°C에서 안정. IL-31 관련 면역 연구 및 사이토카인 신호 전달 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL31/7333 |
| Immunogen | Recombinant fragment (around aa1–164) of human IL31 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Bone marrow colon
- Detected at low levels in: Testis, kidney, skeletal muscle, small intestine, trachea, thymus
- Cellular Location: Secreted
Target Information
Interleukin-31 (IL-31) is a T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells.
IL-31 activity is mediated through ligand-induced oligomerization of a receptor complex containing IL-31 receptor A and oncostatin M receptor.
Upon IL-31 binding, these proteins activate the JAK/STAT and AKT signaling pathways.
IL-31 receptor A and oncostatin M receptor RNA levels are induced in activated monocytes but are constitutively expressed in epithelial cells.
Overexpression of IL-31 in transgenic mice leads to pruritis, alopecia, and skin lesions, and in humans may contribute to atopic dermatitis, suggesting IL-31 as a potential target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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