Thermo Fisher Scientific Interleukin-31/IL-33 Monoclonal Antibody (IL31/7333)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

IL31/7333

Immunogen

Recombinant fragment (around aa1-164) of human IL31 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL-31,uniProtId:Q6EBC2-1,ncbiNodeId:9606,antigenRange:1-164,antigenLength:164,antigenImageFileName:386653-MSM3-P0_IL-31_Q6EBC2-1_House_mouse.svg,antigenImageFileNamePDP:386653-MSM3-P0_IL-31_Q6EBC2-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: bone marrow colon Detected at low levels in testis kidney skeletal muscle small intestine and trachea. thymus

Cellular Location: Secreted.

Target Information

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.