Thermo Fisher Scientific TRAF6 Polyclonal Antibody
TRAF6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP 등 다양한 응용에 적합. 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태의 비결합 항체. 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 3 publications |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Raised against the C-terminal region of human TRAF6 (UniProt ID: Q9Y4K3-1, antigen length 522 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533354 |
Target Information
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are adaptor proteins linking the TNF receptor superfamily to signaling pathways, playing crucial roles in regulating cell death and stress responses. TRAF proteins share a conserved region enabling interactions with cell receptors and other TRAFs, activating distinct signaling cascades.
TRAF2 and TRAF3 bind directly to CD40, a receptor involved in B cell immunity and NF-κB activation in mouse B lymphocytes. TRAF2 and TRAF6 are essential for CD40 signaling in non-hematopoietic cells. TRAF2 also interacts with lymphotoxin-beta receptor (LTβR) alongside TRAF3 and apoptosis regulators cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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