Thermo Fisher Scientific PSMD14 Polyclonal Antibody
PSMD14 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP에 사용 가능. 인간 POH1 C-말단을 면역원으로 제작. 연구용으로만 사용 가능하며 -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Rodent |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Raised against the C-term of human POH1 (PSMD14, UniProt ID: O00487-1, antigen length: 310 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2533352 |
Target Information
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast), a subunit of the 19S complex, mediates substrate deubiquitination during proteasomal degradation. POH1 is a Zn²⁺-dependent protease, differing from other cysteine-type deubiquitinating enzymes (DUBs). It was identified as the human homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs and ultraviolet light when overexpressed in mammalian cells. POH1-induced drug resistance is mediated through AP-1 transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- Antigen Image: 38-0200_PSMD14_O00487-1_Rabbit.svg
- PDP Image: 38-0200_PSMD14_O00487-1_Rabbit_PDP.jpeg
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