Thermo Fisher Scientific Desmin Monoclonal Antibody (D33)
Desmin 단백질을 검출하는 고특이성 Mouse Monoclonal Antibody (Clone D33). 다양한 조직 및 종에서 IHC, ICC, WB 등 다중 응용 가능. Protein A/G 정제, PBS 기반 액상 형태. 연구용으로 근육세포 특이적 단백질 분석에 적합.
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Thermo Fisher Scientific Desmin Monoclonal Antibody (D33)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 53 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 2 publications |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | 16 publications |
| Flow Cytometry (Flow) | - | 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Cat, Hamster, Human, Non-human primate, Rat |
| Published Species | Cat, Chicken, Dog, Human, Mouse, Non-human primate, Rabbit, Rat, Sheep |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | D33 |
| Immunogen | Desmin from human muscle |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_11000611 |
Product Specific Information
MA5-13259 targets Desmin in IF and IHC (P) applications and shows reactivity with Bovine, Canine, Chicken, Feline, Hamster, Human, Non-human primate, and Rat samples.
The MA5-13259 immunogen is desmin from human muscle.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly confined to muscle cells (cardiac, skeletal, and smooth muscle).
Its expression is stage and tissue-specific, induced during terminal development of skeletal muscle differentiation.
In skeletal and cardiac muscle cells, desmin localizes to the Z-disk region and intercalated disk.
Expression in smooth muscle is more heterogeneous.
Coexpression of vimentin and desmin occurs in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas.
During myocardial dysfunction, dramatic changes in desmin distribution have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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