Thermo Fisher Scientific Rb1 (Tumor Suppressor Protein) Monoclonal Antibody (SPM353)
Rb1 종양 억제 단백질을 검출하는 단클론 항체로, Western blot, IHC, IP 등 다양한 응용에 적합. 인간 및 생쥐 시료 반응성. 단클론 IgG1, kappa 아이소타입. 단백질 A/G 정제, PBS 용액 형태로 제공. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunoprecipitation (IP) | 0.5–1 µg/500 µg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM353 |
| Immunogen | Recombinant human Rb1 protein fragment of 283 amino acid residues |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Rb (Retinoblastoma protein) is a tumor suppressor nuclear phosphoprotein that binds to DNA. It is phosphorylated on serine and threonine residues, but not on tyrosine. Rb forms complexes with SV40 large T antigen, adenovirus E1A, and HPV-16 E proteins. It plays a role in transcriptional regulation, and loss of Rb function leads to uncontrolled cell growth. Mutations or aberrations in the RB gene are associated with cancers of the breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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