Thermo Fisher Scientific Phospho-GRK2 (Ser670) Recombinant Rabbit Monoclonal Antibody (HL1035)
GRK2 단백질의 인산화(Ser670) 상태를 검출하는 재조합 토끼 단클론 항체. Western blot 및 IHC(P)에서 검증됨. Human 및 Mouse 시료에 반응. Protein A로 정제된 액상 항체로, 장기 보관 시 -20°C 이하에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1035 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GRK2 (phospho Ser670). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911500 |
Product Specific Information
Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.
Target Information
ADRBK1 (GRK2) is a serine/threonine kinase. Many G protein-coupled receptors (GPCRs) are phosphorylated by G protein-dependent receptor kinases (GRKs).
GRK2 (83 kDa), one of six identified members, is ubiquitously expressed in mammals.
After ligand binding and interaction with heterotrimeric G proteins, GPCRs are phosphorylated by GRKs.
Internalization of GPCRs, regulated by beta-arrestin-1, activates the Ras–Raf–ERK1&2 signaling pathway.
GRK2 activity is tightly regulated by phosphorylation (PKC, Src, ERK1&2) and protein interactions.
ERK phosphorylates and inactivates GRK2 on serine 670 in a negative feedback mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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