Thermo Fisher Scientific CD3e (T-Cell Marker) Recombinant Rabbit Monoclonal Antibody (C3e/4652R)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Does not react with Cat or Dog.

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits (CD3γ, CD3δ, CD3ε, and CD3ζ).
These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
The CD3 components have long cytoplasmic tails that associate with signal transduction molecules via a double tyrosine-based motif.
CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation.
The CD3 antigen is present on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but is not expressed on B or NK cells.
Decreased T lymphocyte percentages may be observed in some autoimmune diseases.
Genes encoding CD3ε, γ, and δ polypeptides are located on chromosome 11.
Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.