Thermo Fisher Scientific AIPL1 Monoclonal Antibody (OTI2D11), TrueMAB
AIPL1 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot, ICC/IF, Flow Cytometry에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. PBS buffer에 trehalose 포함, -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D11 |
| Immunogen | Full length human recombinant protein of human AIPL1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
AIPL1 (Aryl hydrocarbon receptor-interacting protein-like 1) is a tetratricopeptide repeat protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder affecting photoreceptor development.
It is homologous to ARA9, involved in HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor.
AIPL1 forms chaperone complexes with Hsp90 and Hsp70 and associates with the cell cycle regulator NUB1. These interactions are essential for normal photoreceptor maturation, and mutations disrupting these functions lead to LCA.
At least three isoforms of AIPL1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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