Thermo Fisher Scientific SIX5 Polyclonal Antibody
Thermo Fisher Scientific의 SIX5 폴리클로날 항체는 Mouse 및 Rat 시료에서 SIX5 단백질을 검출하기 위한 고품질 Rabbit IgG 항체입니다. Western blot과 ELISA에 적합하며, 세포 내 위치 연구와 전사 조절 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–170 of human SIX5 (NP_7870712) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806264 |
Product Specific Information
Immunogen sequence:
MATLPAEPSA GPAAGGEAVA AAAATEEEEE EARQLLQTLQ AAEGEAAAAA GAGAGAAAAG AEGPGSPGVP GSPPEAASEP PTGLRFSPEQ VACVCEALLQ AGHAGRLSRF LGALPPAERL RGSDPVLRAR ALVAFQRGEY AELYRLLESR PFPAAHHAFL QDLYLRARYH
Positive Samples: Mouse eye, Rat eye
Cellular Location: Cytoplasm, Nucleus
Target Information
Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP, is a transcription factor expressed in various structures of the adult eye.
Localized to the cytoplasm in early development and to the nucleus in later stages, Six5 regulates organogenesis and retinal maintenance.
It binds the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters to control transcription.
Regulated through interaction with DACH1 and co-activated by EYA proteins.
Defects in SIX5 cause branchio-oto-renal syndrome type 2 (BOR2), characterized by hearing loss, deep overbite, and myopia.
Two isoforms exist due to alternative splicing.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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