Thermo Fisher Scientific Phospho-Beclin 1 (Ser234) Polyclonal Antibody
Beclin 1 단백질의 Ser234 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫드에 반응하며 자가포식 연구에 활용됩니다. 친화 크로마토그래피로 정제된 액상 항체로, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:250 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser234 of human BECN1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552703 |
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse, non-human primate, rat, and sheep based on 100% sequence homology.
In Western blot, additional bands may be observed when using non-immunoprecipitated lysates.
Target Information
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.
Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways:
- PI3KC3-C1 is involved in the initiation of autophagosomes.
- PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis.
Beclin 1 also plays a role in antiviral host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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