Thermo Fisher Scientific Phospho-ATP1A1 (Tyr260) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of ATP1A1 only when phosphorylated at Tyr260.

Target Information

The protein encoded by this gene belongs to the family of P-type cation transport ATPases and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining electrochemical gradients of Na⁺ and K⁺ ions across the plasma membrane. These gradients are essential for osmoregulation, sodium-coupled transport of various molecules, and electrical excitability of nerve and muscle cells. The enzyme consists of two subunits: a large catalytic alpha subunit and a smaller glycoprotein beta subunit. The catalytic subunit of Na⁺/K⁺-ATPase is encoded by multiple genes, and this gene encodes the alpha 1 subunit. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.