Thermo Fisher Scientific SPINK5 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SPINK5

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647861

Product Specific Information

Immunogen sequence: DGRLGCTREN DPVLGPDGKT HGNKCAMCAE LFLKEAENAK REGETRIRRN AEKDFCKEYE KQVRNGRLFC TRESDPVRGP DGRMHGNKCA LCAEIFKQRF SEENSKTDQN

Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.

Target Information

Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.