Thermo Fisher Scientific TPM3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
AERLQREVEG ERRAREQAEA EVASLNRRIQ LVEEELDRAQ ERLATALQKL EEAEKAADES ERGMKVIENR ALKDEEKMEL QEIQLKEAKH IAEEADRKYE EVARKLVIIE GDLERTEERA ELAESRCREM DEQIRLMDQN LKCLSA

Highest antigen sequence identity to the following orthologs:

• Mouse: 100%
• Rat: 100%

Target Information

TPM3 (tropomyosin 3) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.