Thermo Fisher Scientific ERBB4 Monoclonal Antibody (OTI1D9), TrueMAB
ERBB4 단백질을 인식하는 마우스 단클론 항체로, Western blot 분석에 적합합니다. Human 시료에 반응하며, 고순도의 액상 형태(1 mg/mL)로 제공됩니다. PBS, BSA, 글리세롤 완충액에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 992–1308 of human ERBB4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing cellular responses such as mitogenesis and differentiation.
It acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation of itself.
Like other protein kinases, ERBB4 regulates cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
ERBB4 is predominantly expressed in several breast carcinoma cell lines and in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
High expression is found in breast tumor cell lines T47-D, MDA-MB-453, BT-474, and H3396, with intermediate levels in MCF-7, MDA-MB-330, and MDA-MB-361.
Low or absent expression is observed in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3 cell lines.
Elevated ERBB4 levels in certain tumor cell lines suggest a potential role in malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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