Thermo Fisher Scientific ERBB4 Monoclonal Antibody (OTI1H6), TrueMAB
ERBB4 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, 인체 시료에 반응합니다. IHC(P)에서 1:1,000 희석으로 사용 가능하며, TrueMAB 형식으로 고순도 친화 크로마토그래피 정제 제품입니다. PBS 기반 버퍼에 보관하며 연구용으로 적합합니다.
- 카탈로그번호
- TA804606
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 992–1308 of human ERBB4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing a variety of cellular responses such as mitogenesis and differentiation.
ErbB4 acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation.
It plays key roles in signal transduction, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
ERBB4 is predominantly expressed in several breast carcinoma cell lines, as well as in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
Breast tumor cell lines T47-D, MDA-MB-453, BT-474, and H3396 show high mRNA levels, while MCF-7, MDAMB-330, and MDA-MB-361 show intermediate levels.
Low or absent expression is observed in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ERBB4 levels in certain human tumor cell lines suggest its potential role in malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(원본에 명시된 항원 이미지 파일: TA804606_ErbB4_Q15303-1_House_mouse_PDP.jpeg)
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