Thermo Fisher Scientific ERBB4 Monoclonal Antibody (OTI1H6), TrueMAB

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000

Product Specifications

Target Information

Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing a variety of cellular responses such as mitogenesis and differentiation.
ErbB4 acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation.
It plays key roles in signal transduction, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.

ERBB4 is predominantly expressed in several breast carcinoma cell lines, as well as in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
Breast tumor cell lines T47-D, MDA-MB-453, BT-474, and H3396 show high mRNA levels, while MCF-7, MDAMB-330, and MDA-MB-361 show intermediate levels.
Low or absent expression is observed in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ERBB4 levels in certain human tumor cell lines suggest its potential role in malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(원본에 명시된 항원 이미지 파일: TA804606_ErbB4_Q15303-1_House_mouse_PDP.jpeg)