Thermo Fisher Scientific GATA2/GATA3 Recombinant Rabbit Monoclonal Antibody (23GB5730)
GATA2/GATA3 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot에 최적화되어 있습니다. HEK293F 발현 시스템에서 생산되며, 인간, 마우스, 랫트에 반응합니다. 액상 형태로 제공되며, PBS/glycerol 버퍼에 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5730 |
| Immunogen | A synthesized peptide derived from human GATA2/3 (1–250AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 is an enhancer-binding protein containing a zinc finger domain and is abundantly expressed in the T-lymphocyte lineage, participating in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by two separate exons highly conserved with those of GATA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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