Thermo Fisher Scientific Growth Hormone Recombinant Rabbit Monoclonal Antibody (GH, 4886R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution

• 1–2 µg/mL

Product Specifications

Product Specific Information

• For immunohistochemistry on PFA-fixed tissues: incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones involved in growth control.
The GH1 gene and four related genes are located at the growth hormone locus on chromosome 17, sharing high sequence identity.
Alternative splicing produces five isoforms (19–24 kDa).
hGH is secreted by pituitary somatotroph cells and acts via cytokine receptor subfamily membrane receptors.
It stimulates liver and other tissues to secrete IGF-1, promoting muscle differentiation, proliferation, amino acid uptake, and protein synthesis.
Mutations or deletions in GH1 can lead to growth hormone deficiency and short stature.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.