Thermo Fisher Scientific alpha-1 Antitrypsin Monoclonal Antibody (1AT11-209.3)

Applications

• ELISA (ELISA)
  Tested Dilution: 1–10 µg/mL

Product Specifications

Product Specific Information

• MA1-10627 detects alpha-1 Antitrypsin from human samples.
• MA1-10627 has been successfully used in ELISA applications.
• The immunogen is purified human serum alpha-1 Antitrypsin.

Target Information

Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress of the newborn.
Increased levels of alpha-1-AT occur as an acute phase response to tissue necrosis and inflammation. Serum levels are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.