Thermo Fisher Scientific alpha-1 Antitrypsin Monoclonal Antibody (1AT11-209.3)
인간 유래 alpha-1 Antitrypsin을 인식하는 Mouse monoclonal antibody입니다. ELISA에 적합하며, Protein A로 정제된 액상 형태입니다. PBS(pH 7.4)에 보존제 없이 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1AT11-209.3 |
| Immunogen | Purified human serum alpha-1 Antitrypsin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070306 |
Product Specific Information
- MA1-10627 detects alpha-1 Antitrypsin from human samples.
- MA1-10627 has been successfully used in ELISA applications.
- The immunogen is purified human serum alpha-1 Antitrypsin.
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress of the newborn.
Increased levels of alpha-1-AT occur as an acute phase response to tissue necrosis and inflammation. Serum levels are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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