Thermo Fisher Scientific Trypsin 2 Monoclonal Antibody (410322)

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunoprecipitation (IP)

12.5 µg/500 µg cell lysate

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

410322

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Trypsin 2/PRSS2 Ala16-Ser247 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Trypsin 2,uniProtId:P07478-1,ncbiNodeId:9606,antigenRange:16-247,antigenLength:247,antigenImageFileName:MA5-24148_Trypsin_2_P07478-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24148_Trypsin_2_P07478-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609645

Product Specific Information

This antibody does not cross-react with recombinant human (rh) Trypsin 1 or rhTrypsin 3. This antibody recognizes both the pro and mature forms of rhTrypsin 2.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.