Thermo Fisher Scientific IGF1R Monoclonal Antibody (OTI11E4), TrueMAB
IGF1R 단백질을 표적하는 Mouse IgG1 단클론 항체로, Western blot 및 Flow cytometry에 사용 가능. 인간 시료 반응성. 동결건조 형태로 공급되며, 재구성 후 약 1 mg/mL 농도. 암 연구 및 IGF1R 신호전달 분석용 연구용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11E4 |
| Immunogen | Human recombinant protein fragment (aa 741–935 of human IGF1R, produced in insect cells) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers.
It forms a tetramer of two α and two β subunits. The α-subunits bind IGF-1 with higher affinity than IGF-2, inducing conformational change and autophosphorylation at residues 1134–1136.
Activated IGF1R phosphorylates substrate proteins, triggering RAS–RAF–MAPK pathways (ERK, p38, JNK) and driving gene transcription related to cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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