Thermo Fisher Scientific IGF1R Monoclonal Antibody (OTI11E4), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers.
It forms a tetramer of two α and two β subunits. The α-subunits bind IGF-1 with higher affinity than IGF-2, inducing conformational change and autophosphorylation at residues 1134–1136.
Activated IGF1R phosphorylates substrate proteins, triggering RAS–RAF–MAPK pathways (ERK, p38, JNK) and driving gene transcription related to cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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