Thermo Fisher Scientific MDMX Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

PA5-19473 targets MDMX in IF and WB applications and shows reactivity with Human samples.
The PA5-19473 immunogen is synthetic peptide conjugated to KLH derived from within residues 200–300 of Human MDMX.
PA5-19473 detects MDMX which has a predicted molecular weight of approximately 80 kDa.

Target Information

The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2.
The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas.
ARF interacts with MDMX to sequester MDMX within the nucleolus, resulting in an increase in p53 transactivation.
Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation.
Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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