Thermo Fisher Scientific Syntaxin-1A-1B Polyclonal Antibody
Rabbit polyclonal antibody recognizing Syntaxin-1A and Syntaxin-1B. Validated for WB and IHC in human, mouse, and rat samples. Lyophilized form without preservative, suitable for research use only. Stable at -20°C with optional glycerol addition.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 60–110 of mouse Syntaxin-1A conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Peptide is homologous in rat and human.
- Specificity: Syntaxin-1A and Syntaxin-1B.
Target Information
Syntaxin-1A/1B are members of the syntaxin superfamily, nervous system-specific proteins involved in docking synaptic vesicles with the presynaptic plasma membrane. They contain a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent manner and interact with voltage-dependent calcium and potassium channels via the C-terminal H3 domain. These proteins play a key role in ion channel regulation and synaptic exocytosis. Alternatively spliced variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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