Thermo Fisher Scientific TIM-1 Polyclonal Antibody
Human TIM-1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC 등 다양한 응용에 적합함. 항원 친화 크로마토그래피로 정제된 액상 시약이며, PBS 버퍼에 0.02% sodium azide 포함. 인체 자궁 조직을 양성 대조로 권장.
- 카탈로그번호
- PA520244
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TIM-1 Polyclonal Antibody
Thermo Fisher Scientific TIM-1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–8 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50 | View publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the amino terminus of human TIM-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152868 |
Product Specific Information
- Suggested positive control: human uterus tissue lysate
- Compatible blocking peptide: PEP-0363
- Immunogen located within amino acids 50–100 of TIM-1
- Predicted molecular weight: ~44 kDa
- Observed band in Western blot: 60 kDa (post-modification: 4 N-linked glycosylation)
- Predicted species reactivity based on immunogen sequence: Mouse (63%), Rat (56%)
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 acts as a receptor or co-receptor for various viruses including hepatitis A/C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Virus binding occurs via phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity.
CD365 is implicated in T-cell co-stimulation and is primarily expressed in epithelial cells, notably in A549, 769-P, and Caco-2 cell lines.
A soluble form of CD365 is generated by metalloproteinase-mediated cleavage of the surface protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.