Thermo Fisher Scientific TIM-1 Polyclonal Antibody

Thermo Fisher Scientific TIM-1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: human uterus tissue lysate
• Compatible blocking peptide: PEP-0363
• Immunogen located within amino acids 50–100 of TIM-1
• Predicted molecular weight: ~44 kDa
• Observed band in Western blot: 60 kDa (post-modification: 4 N-linked glycosylation)
• Predicted species reactivity based on immunogen sequence: Mouse (63%), Rat (56%)

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 acts as a receptor or co-receptor for various viruses including hepatitis A/C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Virus binding occurs via phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity.
CD365 is implicated in T-cell co-stimulation and is primarily expressed in epithelial cells, notably in A549, 769-P, and Caco-2 cell lines.
A soluble form of CD365 is generated by metalloproteinase-mediated cleavage of the surface protein.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.