Thermo Fisher Scientific TMEM66 Polyclonal Antibody
TMEM66 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간 시료에 반응하며, ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용 전용 제품.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TMEM66. Recombinant protein control fragment (Product #RP-105987) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664355 |
Product Specific Information
Immunogen sequence:
YSPPPYSEYPP FSHRYQRFTN SAGPPPPGFK SEFTGPQNTG HGATSGFGSA FT
Highest antigen sequence identity to the following orthologs:
- Mouse: 75%
- Rat: 70%
Target Information
Gene: Saraf (TMEM66)
Saraf encodes a protein that acts as a negative regulator of store-operated Ca²⁺ entry (SOCE), protecting cells from Ca²⁺ overfilling. Upon cytosolic Ca²⁺ elevation after endoplasmic reticulum refilling, it promotes slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity. It may facilitate the de-oligomerization of STIM to effectively turn off ORAI channels when ER Ca²⁺ levels are restored, preventing excessive intracellular Ca²⁺ accumulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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