Thermo Fisher Scientific EpCAM (CD326) Chimeric Recombinant Rabbit Monoclonal Antibody (HEA125)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: This antibody is specific for the extracytoplasmic part of human EpCAM, a stable and widely distributed marker expressed on the surface of many adenocarcinomas. It reacts with carcinomas derived from the colorectum, stomach, pancreas, liver, lung, mammary gland, ovary, thyroid, kidney, urinary bladder, and prostate.

Target Information

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa. It functions as an epithelial cell adhesion molecule and plays roles in cell cycle regulation, proliferation, and metabolism through induction of c-myc and cyclins A and E. Ep-CAM mediates Ca²⁺-independent homotypic interactions and negatively regulates cadherin-mediated adhesions, influencing epithelial differentiation and growth. Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for tumors of epithelial origin. It is found on the basolateral surface of most simple epithelia and many carcinoma types, and is useful in distinguishing adenocarcinomas from pleural mesotheliomas.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.