Thermo Fisher Scientific AIRE Polyclonal Antibody
AIRE 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. 합성 펩타이드(aa 100–150)를 면역원으로 제작되었으며, 동결건조 형태로 제공됩니다. 4°C 단기 보관, 장기 보관은 -20°C 권장. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 100–150 of human AIRE conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: AIRE.
Target Information
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer. It may be involved in the regulation of gene expression.
AIRE is a nuclear protein composed of 545 amino acids with an HSR domain, two PHD-type zinc fingers, and a SAND domain. It may exist in soluble high-molecular-weight complexes and form homodimers, homotetramers, and nuclear bodies.
AIRE interacts with transcriptional coactivators CBP and CREBBP. Three isoforms of AIRE are reported, one of which may be a candidate for nuclear-mediated decay (NMD).
AIRE is involved in immune regulation and mediates E3 ubiquitin ligase activity. Defects in AIRE cause the rare autosomal-recessive autoimmune disease known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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