Thermo Fisher Scientific AIRE Polyclonal Antibody
AIRE 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 사람, 생쥐, 랫트 반응성을 가지며, 합성 펩타이드(aa 30-80)를 면역원으로 사용했습니다. 동결건조 형태로 제공되며 연구용으로만 사용 가능합니다.
- 카탈로그번호
- OSA00238W-100UL
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 30–80 of human AIRE conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at −20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water and centrifuge to remove insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: AIRE.
Target Information
AIRE is a transcriptional regulator protein that binds DNA as a dimer and tetramer, and may regulate gene expression. It is a nuclear protein with 545 amino acids containing an HSR domain, two PHD-type zinc fingers, and a SAND domain. AIRE may form homodimers, homotetramers, and nuclear bodies, interacting with transcriptional coactivators CBP and CREBBP. Three isoforms are reported, one predicted to be a candidate for nuclear-mediated decay (NMD). AIRE plays a role in immune regulation and mediates E3 ubiquitin ligase activity. Mutations in AIRE cause autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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