Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC/7855R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24.
It is commonly activated in various tumor cells and plays a crucial role in:

• Cellular proliferation, differentiation, apoptosis, and cell cycle progression
• Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK
• Vasculogenesis and angiogenesis during tumor development

The deregulated expression of c-Myc induces apoptosis and contributes to neoplastic transformation.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino- or carboxy-termini of targeted proteins.
Amplification or translocation of the c-Myc gene is associated with various human cancers, including:

• Lung, breast, colon carcinomas
• Neuroblastomas (N-Myc amplification)
• Burkitt’s lymphoma and other B-cell lymphoproliferative disorders

Aberrant c-Myc expression occurs in tumors of multiple origins such as colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.