Thermo Fisher Scientific c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC2895R)
Thermo Fisher Scientific의 c-Myc Oncoprotein Recombinant Rabbit Monoclonal Antibody (MYC2895R)는 인간 c-Myc 단백질을 인식하는 고특이성 항체로, ICC/IF, Flow Cytometry, ELISA에 적합합니다. 재조합 단일클론 형태로 높은 순도와 안정성을 제공하며, 종 특이적으로 인간 시료에만 반응합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MYC2895R |
| Immunogen | Synthetic peptide corresponding to aa 408–439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-Myc, coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse, Rat or Chicken.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK influences cell proliferation and cycle regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc can induce apoptosis and is associated with neoplastic diseases.
Amplification of the c-Myc gene has been found in lung, breast, and colon carcinomas, while N-Myc amplification is observed in neuroblastomas. Translocation of the c-Myc locus is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant c-Myc expression occurs in tumors of various origins including colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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