Thermo Fisher Scientific CD16/CD32 Monoclonal Antibody (93), PE, eBioscience
마우스 CD16/CD32 항원을 인식하는 단클론 항체로, PE 형광표지되어 흐름세포분석(Flow Cytometry)에 최적화됨. Rat IgG2a, lambda 아이소타입이며, 0.125 µg/test로 사용 가능. Affinity chromatography로 정제되어 높은 순도와 안정성을 제공.
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Thermo Fisher Scientific CD16/CD32 Monoclonal Antibody (Clone 93), PE, eBioscience™
Applications and Tested Dilution
- Flow Cytometry (Flow): 0.125 µg/test
- Miscellaneous PubMed (Misc): -
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Fruit fly, Mouse, Rat |
| Host / Isotype | Rat / IgG2a, lambda |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 93 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465567 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Biotin
- Brilliant UV 496
- Brilliant UV 661
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Red 685 / 700 / 710 / 755
- NovaFluor Yellow 690
- PE-Cyanine7
- PerCP-Cyanine5.5
- PerCP-eFluor 710
- Super Bright 436 / 600
- Request custom conjugation
Product Specific Information
The 93 monoclonal antibody reacts with an epitope shared by mouse CD16 and CD32.
CD16 (Fc gamma III Receptor) and CD32 (Fc gamma II Receptor) are low-affinity receptors for the mouse IgG Fc portion and are expressed by B cells, monocyte/macrophages, NK cells, and neutrophils.
Applications Reported: Flow cytometric analysis
Applications Tested: Flow cytometric analysis of mouse splenocytes at ≤ 0.125 µg/test.
A test is defined as the amount of antibody that stains a cell sample in 100 µL final volume (10⁵–10⁸ cells/test).
Careful titration recommended for optimal performance.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD16 is a 50–65 kDa cell surface molecule expressed in two forms:
- Transmembranous form: NK cells and some T cells
- Phosphatidylinositol-linked form: Granulocytes
CD16 acts as a low-affinity receptor for IgG (FcR III) and mediates antibody-dependent cellular cytotoxicity (ADCC).
CD32 is a 40 kDa glycoprotein acting as a low-affinity IgG receptor (Fc gamma RII), involved in:
- Endocytosis
- Activation of secretion
- Cytotoxicity and immunomodulation
CD32 is expressed by B cells, monocytes, granulocytes, and platelets.
It plays a key role in phagocytosis of immune complexes and regulation of antibody production by B cells.
Variations in the CD32 gene may increase susceptibility to systemic lupus erythematosus (SLE).
Multiple transcript variants encoding different isoforms of CD32 exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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