Thermo Fisher Scientific TIE2 Polyclonal Antibody, Biotin
TIE2 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, IHC, ELISA 등 다양한 분석에 사용 가능. Mouse 및 Rat 반응성, Chicken 유래 IgY 항체. 고순도 Affinity chromatography 정제, 안정적인 액상 형태로 연구용 적합.
- 카탈로그번호
- TIE2-Y-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Dot blot (DB) | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host/Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 540–590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) containing 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The TEK receptor tyrosine kinase (also known as TIE2) is expressed almost exclusively in endothelial cells. TEK signaling is essential for endothelial cell–smooth muscle cell communication in venous morphogenesis, and mutations in TEK are linked to inherited venous malformations. The ligand angiopoietin-1 binds to TEK and activates pathways critical for embryonic vascular development. TIE2 expression increases in response to thyroid-stimulating hormone and cAMP-elevating agents. Hematopoietic stem cells expressing TIE2 are quiescent, antiapoptotic, and adhere to osteoblasts within the bone marrow niche.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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