Thermo Fisher Scientific Azurocidin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL

Immunoprecipitation (IP)

• Tested Dilution: 25 µg/mL

Product Specifications

Product Specific Information

• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.

Target Information

Azurocidin, also known as heparin-binding protein (HBP), is an inactive homolog of serine proteinases found in granulocytes. Initially recognized for activity against gram-negative bacteria, it also acts against gram-positive bacteria and Candida albicans.
Azurocidin belongs to the family of polymorphonuclear leukocyte-derived antimicrobial proteins such as defensins, LL-37, and lysozyme. It plays a role in immune response activation and modulation, with its cationic domain critical for antimicrobial activity.
Stored in azurophil and secretory granules, it is released early during extravasation and contributes to chemotaxis, monocyte activation, cytokine release, and phagocytosis, enhancing bacterial clearance.
Its interaction with leukocytes is mediated via beta 2-integrins. Elevated plasma levels may help identify patients at risk of developing sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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