Thermo Fisher Scientific GPR65 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human (100%)
• Gorilla, Gibbon (94%)

Target Information

GPR65 (also known as TDAG8) is a transmembrane protein belonging to the G protein-coupled receptor superfamily. It consists of 337 amino acids and shows 90% similarity and 81% identity in the seven transmembrane domains of its mouse homolog.
It has three potential N-linked glycosylation sites and is expressed predominantly in lymphoid organs and cancer tissues, with increased expression during activation-induced death of T-cell hybridomas.
Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a proton-sensing receptor that couples to adenylyl cyclase and psychosine, playing a role in immunological autotolerance and cellular transformation through RhoA activation and actin rearrangement under acidic conditions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.