Thermo Fisher Scientific GPR65 Polyclonal Antibody
Human GPR65 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, PBS 버퍼와 0.1% sodium azide를 포함. 단기 4°C, 장기 -20°C 보관 권장.
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- PA533755
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- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 3rd extracellular domain of human GPR65 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551126 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human (100%)
- Gorilla, Gibbon (94%)
Target Information
GPR65 (also known as TDAG8) is a transmembrane protein belonging to the G protein-coupled receptor superfamily. It consists of 337 amino acids and shows 90% similarity and 81% identity in the seven transmembrane domains of its mouse homolog.
It has three potential N-linked glycosylation sites and is expressed predominantly in lymphoid organs and cancer tissues, with increased expression during activation-induced death of T-cell hybridomas.
Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a proton-sensing receptor that couples to adenylyl cyclase and psychosine, playing a role in immunological autotolerance and cellular transformation through RhoA activation and actin rearrangement under acidic conditions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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