Thermo Fisher Scientific GPR65 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))
  Tested Dilution: 10–20 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Panda, Horse, Pig (94%).

Target Information

GPR65, also known as TDAG8, is a transmembrane protein belonging to the G protein coupled receptor superfamily. It consists of 337 amino acids and shows 90% similarity and 81% identity in the seven transmembrane domains of its mouse homolog.
It has three potential N-linked glycosylation sites and is expressed predominantly in lymphoid organs and cancer tissues, with increased expression during activation-induced death of T-cell hybridomas.
Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a novel proton-sensing receptor, coupling to adenylyl cyclase and psychosine, and plays a role in immunological autotolerance.
Additionally, GPR65 is involved in cellular transformation by RhoA activation and actin rearrangement under conditions of tissue acidosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.