Thermo Fisher Scientific SSX4B Monoclonal Antibody (OTI2E10), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

SSX4B belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins, which may act as transcriptional repressors. These proteins can elicit spontaneous humoral and cellular immune responses in cancer patients and are potential targets for cancer vaccine-based immunotherapy.
SSX1, SSX2, and SSX4 genes are involved in the t(X;18) translocation found in synovial sarcomas, resulting in fusion of the synovial sarcoma translocation gene on chromosome 18 with one of the SSX genes on chromosome X. Chromosome Xp11 contains segmental duplication producing two identical copies, SSX4 and SSX4B, arranged tail-to-tail. SSX4B represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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