Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (rESR1/7162)
인체 유래 에스트로겐 수용체 알파(ERα)를 표적하는 마우스 단클론 항체로, 에스트로겐 의존성 마커 연구에 적합. IHC(PFA 고정)에서 1–2 µg/mL 농도로 사용 가능. 고순도 Protein A/G 정제, 액상 형태로 제공. 4°C 보관, 동결 금지.
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Applications
Immunohistochemistry (PFA fixed)
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rESR1/7162 |
| Immunogen | Recombinant fragment corresponding to C-terminus of human ER-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
ER can positively or negatively regulate gene transcription through recruitment of coactivator or corepressor proteins.
There are two forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). At least four estrogen receptor-alpha isoforms are known:
- Isoform 1 (66 kDa)
- Isoform 2 (53 kDa)
- Isoform 3 (47 kDa)
- Isoform 4 (35 kDa)
Estrogen receptors are widely expressed and essential for sexual development and reproductive function, also playing roles in bone and various pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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