Thermo Fisher Scientific LATS1 Polyclonal Antibody
LATS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 적합합니다. 인간 LATS1의 50–100번 잔기 영역을 면역원으로 사용하였으며, 액상 형태로 제공됩니다. 4°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:15,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 50 and 100 of human Large Tumor Suppressor homolog 1 (LATS1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis, being phosphorylated in a cell-cycle dependent manner.
The N-terminal region binds CDC2 to form a complex with reduced H1 histone kinase activity, suggesting a role as a negative regulator of CDC2/cyclin A.
The C-terminal kinase domain binds to its own N-terminal region, indicating potential negative regulation through intramolecular binding.
LATS1 acts as a tumor suppressor and plays an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors, and sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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