Thermo Fisher Scientific DDX3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:15,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan, and Chimpanzee

Target Information

The protein encoded by this gene is a member of the large DEAD-box protein family, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif and ATP-dependent RNA helicase activity. It exhibits high RNA-independent ATPase activity and is stimulated by both RNA and DNA.
This protein functions in both nucleus and cytoplasm, participating in:

• Transcriptional regulation
• mRNP assembly
• Pre-mRNA splicing
• mRNA export
• Translation, cellular signaling, and viral replication

Misregulation of this gene has been implicated in tumorigenesis. A paralog exists on the Y chromosome, and pseudogenes are found on chromosomes 4 and X. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.