Thermo Fisher Scientific LMX1B Polyclonal Antibody
LMX1B 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 생쥐 시료에 반응하며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LMX1B (Accession O60663), corresponding to amino acid residues Q162–D212 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850510 |
Product Specific Information
This antibody detects endogenous levels of total LMX1B.
Target Information
LMX1B (LIM homeobox transcription factor 1B) belongs to the LIM-homeodomain family, which plays a key role in developmental pattern formation. LMX1B regulates mid-hindbrain patterning, and LMX1B-deficient mouse embryos show a severe reduction in midbrain dopaminergic neurons compared to wild-type. LMX1B is essential for both development and survival of dopamine neurons, while the related LMX1A is critical for their differentiation. Together, LMX1A and LMX1B cooperatively regulate the proliferation, specification, and differentiation of midbrain dopaminergic neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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