Thermo Fisher Scientific Human CENPO Synthetic Peptide
인간 CENPO 단백질의 중심부 16개 아미노산 서열로 구성된 합성 펩타이드. PA5-20826 항체의 블로킹 펩타이드로 사용 가능. 액상 형태로 제공되며 PBS 버퍼에 0.1% BSA와 0.02% sodium azide 포함. -20°C에서 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the center of human CENPO.
PEP-0940 can be used as a blocking peptide with polyclonal antibody PA5-20826.
Target Information
Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies (ACA) positive patients with scleroderma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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