Thermo Fisher Scientific Human RUSC1 Synthetic Peptide
인간 RUSC1 단백질의 C-말단 17개 아미노산 서열에 해당하는 합성 펩타이드. 항체 차단 실험용으로 사용 가능하며, 정제된 액상 형태로 제공. PBS 버퍼(pH 7.2) 내 0.1% BSA 및 0.02% sodium azide 포함. -20°C에서 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human RUSC1.
PEP-0936 can be used as a blocking peptide with polyclonal antibody PA5-20822.
Target Information
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper, and SH3 domain, with over 30% amino acid identity.
RUSC1 is an adapter protein that binds to the TrkA receptor and is required for NGF-induced neurite growth in PC12 cells.
It interacts with Ikappa-B kinase (IKK)-gamma, the regulatory subunit of the IKK complex involved in NF-kappa-B activation in signaling pathways such as TNF-R or TLR.
RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, catalyzing RUSC1 polyubiquitination. Overexpression of RUSC1 inhibits TRAF6-mediated polyubiquitination of IKK-gamma, suggesting RUSC1 may play a role in the IKK-gamma-mediated NF-kappa-B activation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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