Thermo Fisher Scientific PCP4 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 PCP4 폴리클로날 항체. IHC(P), IHC(F) 등 다양한 면역조직화학 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PCP4. Recombinant protein control fragment (Product #RP-88803). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645298 |
Product Specific Information
Immunogen sequence:
GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates calcium-dependent binding properties of CaM and regulates calcium association/dissociation rates from the C-terminal domain of CaM. The IQ motif contains a serine residue phosphorylated by all isoforms of protein kinase C (PKC).
PCP-4 is implicated in uterine leiomyomas and neurodegenerative disorders such as Alzheimer’s and Huntington’s diseases. Overexpression of PCP-4 is also associated with cerebellar hypoplasia, a characteristic feature of Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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