Thermo Fisher Scientific GART Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
LGDLLLTPTR IYSHSLLPVL RSGHVKAFAH ITGGGLLENI PRVLPEKLGV DLDAQTWRIP RVFSWLQQEG HLSEEEMART FNCGVGAVLV VSKEQTEQIL RDIQQHKEEA WVIGSVVARA EGSPRVKVKN LIESMQINGS VLKNGSLT

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 78%
  • Rat: 82%

Target Information

MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1, or GAS6. It regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding induces autophosphorylation of MERTK on its intracellular domain, creating docking sites for downstream signaling molecules. Following activation, it interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling plays roles in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. In retinal pigment epithelium (RPE), it regulates rod outer segment fragment phagocytosis and suppresses TLR-mediated innate immune response via STAT1 activation and SOCS1/3 induction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.