Thermo Fisher Scientific Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag Recombinant Protein
인간 MAP3K7/MAP3K7IP1 (TAK1-TAB1) 재조합 단백질로, His-tag가 부착된 형태입니다. 인산화 효소 활성 분석(Kinase Assay)에 적합하며, 염증 및 세포 신호전달 연구에 활용됩니다. 곤충 세포에서 발현된 정제 단백질로, -80°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | 1–596 |
| Tag | His-tag |
| Molecular Weight | 45.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | 55% by SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris (pH 7.5), 0.02% Triton X-100, 50% glycerol, 2 mM DTT, 0.5 mM EDTA, 150 mM NaCl |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use from original packaging until exhausted.
- For larger sizes, minimize freeze/thaw cycles by preparing aliquots (not below 20 µL).
- Do not store kinase diluted.
- If properly stored at -80°C, product is guaranteed for 6 months from purchase date.
- Protein Form: Full Length
Target Information
MAP3K7 (TAK1) regulates transcription and apoptosis and is implicated in inflammatory diseases and rheumatoid arthritis. Fusion with MAP3K7IP1 (TAB1) activates MAP3K7. TAK1, originally identified as a TGF-β-activated kinase, interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in p38 and JNK activation through Wnt, BMP, and activin signaling, as well as in response to thyroid hormone, osmotic stress, endothelin, and ephrine. TAB1 regulates MAP3K7/TAK1 and mediates signaling pathways induced by TGF-β, interleukin 1, and WNT-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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