Thermo Fisher Scientific Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag Recombinant Protein

Thermo Fisher Scientific Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent
Publications: [References not provided]

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use from original packaging until exhausted.
• For larger sizes, minimize freeze/thaw cycles by preparing aliquots (not below 20 µL).
• Do not store kinase diluted.
• If properly stored at -80°C, product is guaranteed for 6 months from purchase date.
• Protein Form: Full Length

Target Information

MAP3K7 (TAK1) regulates transcription and apoptosis and is implicated in inflammatory diseases and rheumatoid arthritis. Fusion with MAP3K7IP1 (TAB1) activates MAP3K7. TAK1, originally identified as a TGF-β-activated kinase, interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in p38 and JNK activation through Wnt, BMP, and activin signaling, as well as in response to thyroid hormone, osmotic stress, endothelin, and ephrine. TAB1 regulates MAP3K7/TAK1 and mediates signaling pathways induced by TGF-β, interleukin 1, and WNT-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.