Thermo Fisher Scientific Human MYLK (MLCK), GST Tag Recombinant Protein
Human MYLK (MLCK) GST-tag 재조합 단백질로, myosin light chain 인산화를 통한 근육 수축 연구에 적합합니다. Baculovirus 발현 시스템에서 생산되었으며, 고순도 액상 형태로 제공됩니다. -80°C 보관, kinase assay 등 연구용으로 사용됩니다.
- 카테고리
- Enzymes
- 판매단위
- pk
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Thermo Fisher Scientific Human MYLK (MLCK), GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Publications: [References available upon request]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Baculovirus |
| Amino Acid Sequence | 1428–1771 |
| Tag | GST-tag |
| Molecular Weight | 67.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris (pH 7.5), 0.02% Triton X-100, 150 mM NaCl, 0.5 mM EDTA, 50% glycerol, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, spin prior to use.
- Aliquots below 20 µL are not recommended.
- Do not store kinase diluted.
- If properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
- Protein Form: Catalytic
Target Information
MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains to enable contractile activity through myosin-actin interaction.
It plays a key role in smooth muscle contraction, vascular permeability, tissue edema formation, and signaling pathways leading to fibroblast apoptosis.
MLCK is expressed in various adult and fetal tissues, including smooth muscle and non-muscle cells.
Non-muscle isoform 2 is the dominant splice variant, while the Telokin isoform binds calmodulin.
The protein includes one fibronectin type III domain and nine immunoglobulin-like C2-type domains.
MLCK is likely down-regulated by phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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