Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Tyr537) Monoclonal Antibody (3C6C6)
인간 Estrogen Receptor alpha (Tyr537)을 인식하는 Mouse IgG1 단클론 항체로, ELISA 및 유세포분석에 적합합니다. 단백질 G로 정제된 액상 형태이며, 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Tyr537) Monoclonal Antibody (3C6C6)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 1:200–1:400 | View 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C6C6 |
| Immunogen | Synthesized peptide of human Erα (AA: 530–542, Tyr-537) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787468 |
Product Specific Information
MA5-31845 has been tested in indirect ELISA.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. ERs regulate gene transcription by recruiting coactivator or corepressor proteins.
There are two forms—alpha (ESR1) and beta (ESR2)—encoded by separate genes. Alternative RNA splicing produces at least four known ERα isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa).
Estrogen receptors are expressed in various tissues and are essential for sexual development and reproductive function, as well as playing roles in bone and other tissues. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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