Thermo Fisher Scientific TDP-43 Recombinant Rabbit Monoclonal Antibody (ARC0492)
TDP-43 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, ELISA, IP, ChIP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도 Affinity Chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 400–600 µg extracts |
| ChIP assay (ChIP) | 5 µg antibody for 10–15 µg of chromatin |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0492 |
| Immunogen | Synthetic peptide corresponding to amino acids 300–400 of human TDP-43/TARDB (Q13148) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849175 |
Product Specific Information
Immunogen sequence:
GNNQGSNMGG GMNFGAFSIN PAMMAAAQAA LQSSWGMMGM LASQQNQSGP SGNNQNQGNM QREPNQAFGS GNNSYSGSNS GAAIGWGSAS NAGSGSGFNG G
Target Information
TDP-43 was first identified as a novel cellular protein that binds to the HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor of the HIV-1 LTR.
It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP-43, known as pathologic TDP-43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U).
TDP-43 is distinct from TRBP1, another RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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